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ORIGINAL ARTICLE
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A randomized controlled trial to compare the effect of ultrasound-guided, single-dose platelet-rich plasma and corticosteroid injection in patients with carpal tunnel syndrome


1 Assistant Professor, Department of Physical Medicine and Rehabilitation, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India
2 Additional Professor, Department of Physical Medicine and Rehabilitation, All India Institute of Medical Sciences, New Delhi, India
3 Associate Professor, Department of Physical Medicine and Rehabilitation, All India Institute of Medical Sciences, New Delhi, India
4 Professor & Head, Department of Physical Medicine and Rehabilitation, Mahatma Gandhi Hospital, MGUMST, Sitapura, Jaipur, Rajasthan, India
5 Professor, Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India
6 Associate Professor, Department of Pathology, SGPGI, Lucknow, India

Correspondence Address:
Srikumar Venkataraman,
All India Institute of Medical Sciences, New Delhi
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jisprm.JISPRM-000164

Background: Platelet-rich plasma (PRP) may aid functional recovery in compressive neuropathies. Objective: To compare the effect of autologous PRP with corticosteroid injection in patients with refractory carpal tunnel syndrome (CTS). Materials and Methods: This was a randomized controlled trial on 84 adults, who received either single-dose, ultrasound-guided PRP or corticosteroid. Boston Carpal Tunnel Questionnaire and cross-sectional area of median nerve were assessed at 0, 4, and 12 weeks. Results: A statistically significant 54.76% improvement (P < 0.05) in functional status was observed in both the groups at 12 weeks. Conclusion: PRP is as effective as corticosteroids in relieving pain and improving function in CTS.


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