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Year : 2020  |  Volume : 3  |  Issue : 1  |  Page : 22-27

A combined behavioral and pharmacological approach in nonparaneoplastic-related anti-N-methyl-D-aspartate receptor encephalitis: A case report with positive outcome in a male patient

Department of Rehabilitation Medicine, Tan Tock Seng Hospital, Singapore

Correspondence Address:
Dr. Matthew Rong Jie Tay
Tan Tock Seng Hospital Rehabilitation Center, 17 Ang Mo Kio Ave. 9, 569766
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jisprm.jisprm_3_20

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Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a rare but potentially life-threatening and disabling autoimmune encephalitis mainly affecting young women. We report the case of a male in his early thirties who developed behavioral and neurocognitive manifestations of anti-NMDAR encephalitis. This case highlights the unique behavioral challenges in a male patient during the course of rehabilitation, including impulsivity, inappropriate sexual behavior, and hyperphagia, which has not been well-described in the literature. This presented complex problems for the rehabilitation team and amelioration of these clinical issues required a multidisciplinary approach. The behavioral and pharmacological strategies employed, which had a pronounced positive contribution in this patient, are described. A brief review of the epidemiology, course, and common complications of anti-NMDAR encephalitis is also presented.

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