|Year : 2019 | Volume
| Issue : 1 | Page : 54-61
The benefit of exercise in patients who undergo allogeneic hematopoietic stem cell transplantation
Shinichiro Morishita1, Atsuhiro Tsubaki1, Kazuki Hotta1, Jack B Fu2, Shigeo Fuji3
1 Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan
2 Department of Palliative, Rehabilitation and Integrative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA
3 Department of Hematology, Osaka International Cancer Institute, Osaka, Japan
|Date of Web Publication||22-May-2019|
Prof. Shinichiro Morishita
Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Shimami-cho 1398, Kita-ku, Niigata 950-3198
Source of Support: None, Conflict of Interest: None
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is increasingly used in the treatment of hematologic cancers such as leukemias, lymphomas, and myeloma and for other hematologic disorders such as primary immunodeficiency, aplastic anemia, and myelodysplasia. Allo-HSCT entails a conditioning regimen of frequent high-dose chemotherapy in combination with total body irradiation, followed by infusion of donor-harvested bone marrow or peripheral blood stem cells. As an aggressive and demanding medical therapy that profoundly impacts patient quality of life (QOL), allo-HSCT is associated with numerous treatment-related physical, psychological, and psychosocial side effects. The procedure can result in decreased respiratory and balance function, skeletal muscle strength, and exercise capacity. Thus, as physical exercise has been shown to positively affect physical and psychosocial function and QOL in allo-HSCT patients, it is a recommended intervention for improving essential functions and offsetting lost exercise capacity after the procedure. Furthermore, recent evidence has shown that physical exercise can influence survival rate and mortality in allo-HSCT patients. This review provides an overview of the current research on the effectiveness of physical exercise for allo-HSCT patients.
Keywords: Allogeneic hematopoietic stem cell transplantation, effectiveness, physical exercise
|How to cite this article:|
Morishita S, Tsubaki A, Hotta K, Fu JB, Fuji S. The benefit of exercise in patients who undergo allogeneic hematopoietic stem cell transplantation. J Int Soc Phys Rehabil Med 2019;2:54-61
|How to cite this URL:|
Morishita S, Tsubaki A, Hotta K, Fu JB, Fuji S. The benefit of exercise in patients who undergo allogeneic hematopoietic stem cell transplantation. J Int Soc Phys Rehabil Med [serial online] 2019 [cited 2023 Mar 31];2:54-61. Available from: https://www.jisprm.org/text.asp?2019/2/1/54/254006
| Introduction|| |
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative procedure for a variety of hematologic malignancies, such as leukemia, lymphomas, and myeloma. Allo-HSCT requires hematopoietic cells from a human leukocyte antigen (HLA)-matched or mismatched donor, which are given after the patient receives high-dose chemotherapy and total body irradiation. The HSC used in allo-HSCT must be sourced from a genetically similar, but not identical, donor. Thus, the donor is often a sister or brother but in some cases unrelated.
From 2006 to 2012, the use of allo-HSCT increased by 57% worldwide. When initially developed, allo-HSCT was considered as a novel approach for protecting patients from the toxic side effects of supralethal doses of radiation and chemotherapy by transplanting HSC, which have the ability to reconstitute hematopoiesis. The purpose of transplantation can be to restore hematological function in patients with bone marrow failure states, to replace diseased marrow with healthy donor marrow, as a “rescue” to reconstitute hematological function after marrow-ablative chemoradiotherapy, and most recently, as a means of treating certain genetic and nonmalignant disorders. HSC can be sourced from bone marrow, peripheral blood, or umbilical cord blood.
It has been reported that allo-HSCT achieved lower relapse rates and improved survival in patients with hematologic malignancy with recurrent or refractory disease and those at a high risk of resistance or relapse. Allo-HSCT should be preferred to conventional chemotherapy as a postremission treatment for adults with lymphoblastic lymphoma. However, allo-HSCT is a highly aggressive and demanding medical therapy that profoundly impacts patient quality of life (QOL). Despite the advantages of allo-HSCT for patients with hematologic malignancy, these patients often develop graft-versus-host disease (GVHD), which is commonly observed after allo-HSCT. GVHD causes the donor's cells to attack not only the underlying malignancy or disorder but also to adversely affect the skin, gastrointestinal tract, and liver, and thus, GVHD significantly impacts patients QOL., In addition to possibly developing GVHD, patients who undergo allo-HSCT can experience a range of other side effects [Figure 1]. These include mouth sores, nausea and vomiting, diarrhea, decreased physical function, fatigue, anxiety, dry mouth, hair loss, rashes, and breathing problems., GVHD can manifest as acute or chronic. Acute GVHD usually manifests within 100 days following HSCT, while chronic GVHD typically presents after >100 days after the transplant. Symptoms associated with acute GVHD include skin rash, stomach nausea, diarrhea, and liver problems; in contrast, chronic GVHD symptoms generally include issues with the eyes, lungs, mouth, joints, and muscle function. In addition to the side effects mentioned above, patients who undergo allo-HSCT patients have an increased risk of bleeding and infection. Allo-HSCT patients have decreased physical function and QOL 6–7 weeks after HSCT compared to that before HSCT., Besides GVHD and infections, reduced physical function, and particularly high levels of fatigue, negatively affect patients' QOL. Allo-HSCT patients may require physical exercise to prevent a decrease in physical function or improve physical function and QOL. The purpose of this review was to provide an overview of the current research on the effectiveness of physical exercise for allo-HSCT patients. We used electronic searches of two databases – PubMed and Scopus up to January 8, 2019, to select studies of the effects of exercise for allo-HSCT patients. This review was then conducted using the following words: “hematopoietic stem cell transplantation,” “HSCT,” “exercise,” and “rehabilitation.”
|Figure 1: Physical function associated with treatment-related side effects after allogeneic hematopoietic stem cell transplantation|
Click here to view
| Decreased Physical Function in Allogeneic Hematopoietic Stem Cell Transplantation Patients|| |
Physical function before allogeneic hematopoietic stem cell transplantation or hospital admission
A previous study reported that 110 allo-HSCT patients had significantly decreased muscle strength, exercise capacity, and QOL compared to sex- and age-matched healthy individuals before HSCT. Furthermore, 83 of 164 allo-HSCT patients (50.6%) experienced sarcopenia before allo-HSCT, and these patients experienced decreased muscular strength and increased fatigue after the procedure compared to patients without sarcopenia. Patients with sarcopenia showed significantly lower scores in physical functioning, bodily pain, and vitality in health-related QOL than those without sarcopenia.
Another report showed that factors significantly associated with reduced leg extension strength after allo-HSCT included preprocedure leg extension strength, grade of acute GVHD, age, and time interval between pre- and postevaluation in 88 patients who received allo-HSCT. Patient leg extension strength and peak VO2 were significantly reduced after allo-HSCT. Another study showed that both allogeneic (n = 11) and autologous (n = 11) HSCT patients with lower peak VO2 had higher symptom burdens and inferior QOL during the early post-HSCT period.
The feasibility and preliminary effectiveness of an exercise program for 29 patients before HSCT have also been investigated, and the results showed that patients had a training adherence rate of 69% and that no adverse events or injuries occurred. Thus, exercise before HSCT appears to be safe and feasible, with favorable preliminary effectiveness. Therefore, as decreased physical function before allo-HSCT influences physical function after the procedure, research suggests that physical exercise should be recommended to patients before undergoing allo-HSCT.
| Physical Function After Allogeneic Hematopoietic Stem Cell Transplantation or Hospital Admission|| |
Allo-HSCT patients receive high-dose chemotherapy, total body irradiation, and hematopoietic cells from an HLA-matched or mismatched donor. These patients are hospitalized in a single-bed isolation room for a period of 4–6 weeks, as the severely depressed bone marrow function increases the patient's risk of bleeding, infection, and anemia and results in weakness, fatigue, shortness of breath, and insomnia., In addition, allo-HSCT patients often receive numerous corticosteroid doses to prevent acute GVHD. The number of these doses was significantly correlated with a decrease in handgrip and knee extensor strength in 113 allo-HSCT patients.
The decrease in physical function experienced by patients after allo-HSCT negatively affects activities of daily living (ADL) and QOL [Figure 2]. For example, 30 allo-HSCT patients were shown to have significantly decreased balance function when tested using the Timed Up and Go test, as well as decreased center-of-pressure total trajectory length using the body sway test after transplantation. Balance function is significantly correlated with handgrip and knee extensor strength. Another study, which included 23 allogeneic and 21 autologous HSCT patients, showed that patients had significantly worsened results in the 2-min walking test and grip strength after transplantation. According to that study, these significant differences correspond to decrease in aerobic conditioning before and after physical stress, declines in functioning and gait performance, reduction of muscle strength and spine flexibility, and diminished functioning in ADLs after HSCT.
|Figure 2: Decrease in physical function, disability, and quality of life in patients with allogeneic hematopoietic stem cell transplantation after treatment|
Click here to view
Another report showed that the 6-min walk test (6MWT) and handgrip strength were significantly decreased 6 weeks after allo-HSCT compared to 2 weeks before in 86 allo-HSCT patients and that upper extremity muscle mass and trunk muscle mass were significantly decreased after allo-HSCT. Similarly, another study reported that 64 allo-HSCT patients had significantly decreased handgrip strength and 6MWT scores at the time of discharge from the hospital.
There are also gender differences in QOL after allo-HSCT. Significant gender and time interactions were observed for handgrip strength and muscle mass in 64 allo-HSCT patients, with a much greater handgrip strength and muscle mass decline in men than in women. Another study showed that after allo-HSCT women had significantly lower scores for physical function and general health on health-related QOL tests compared with men in 100 patients (66 men and 34 women) who underwent allo-HSCT. Thus, male allo-HSCT patients may tend to have decreased muscle strength, while female allo-HSCT patients tend to have a decreased health-related QOL.
Fatigue is another common side effect of allo-HSCT. One study showed that fatigue significantly increased and physical activity decreased following high-dose chemotherapy and HSCT in 7 allogeneic and 10 autologous HSCT patients; as a result, patients experienced diminished physical, emotional, role, and cognitive functioning. In addition, the symptoms that patients experienced, such as fatigue, pain, nausea and vomiting, sleep disturbances, appetite loss, and diarrhea, increased during the acute posttransplant period.
The proportion of daily activities performed at an intensity >3.0 metabolic equivalents (METs) has been shown to increase significantly after allo-HSCT in 30 patients. Daily activity time performed at an intensity of 1.6–2.9 METs significantly correlated only with knee strength. The total number of daily steps and the proportion of activity performed at 1.6–2.9 METs and >3.0 METs were positively correlated with the 6MWT. In addition, physical functioning and general health subscales in health-related QOL were found to be positively correlated with daily activities performed at >3.0 METs. For allo-HSCT patients, it may be important to assess physical activity before the procedure and to increase levels and intensity of physical activity to prevent reduced physical function thereafter.
There is recent evidence that allo-HSCT patients have decreased muscle oxygen consumption and decreased blood flow to skeletal muscles after transplantation. Furthermore, there may be a relationship between fatigue and decreased muscle oxygen consumption in patients after allo-HSCT in 25 male patients. Similarly, muscle oxygen hemoglobin saturation was also found to be significantly lower in 18 patients after allo-HSCT, both during and after exercise, which directly affects exercise capacity; however, no difference has been found in total hemoglobin before and after allo-HSCT. As with the effects of decreased muscle oxygen hemoglobin saturation, a decrease in skeletal muscle oxygenation was also associated with a reduction in exercise capacity in 18 allo-HSCT patients. In one study, changes in hemoglobin parameters in the tibialis anterior muscle in 16 patients before allo-HSCT were found to be different from those in 21 age-matched healthy controls; in the healthy control group, there was a correlation between muscle strength and hemoglobin dynamics, but this correlation was not observed in patients before allo-HSCT.
In an investigation of patient physical function and QOL before allo-HSCT in 30 patients undergoing allo-HSCT, at hospital discharge, and 1 year after transplantation, handgrip strength and 6MWT scores were significantly lower at time of discharge than at pretransplantation. However, both returned to pre-HSCT levels within 1 year after HSCT. Similarly, QOL scores also returned to pre-HSCT levels within 1 year after HSCT.
QOL and physical function have also been compared between 126 patients allo-HSCT patients (HID group, n = 100; other donor group, n = 26) who received HSC from an HLA-matched sibling, a matched unrelated donor, or an unrelated umbilical cord blood donor. After the procedure, the haploidentical donor group showed significantly greater improvements in the general health subscale and Mental Component Summary of QOL than the other donor groups. However, the haploidentical donor group actually showed significantly greater decline in handgrip strength and knee extensor muscle strength after HSCT when compared to the other donor groups. From these results, the donor type may affect QOL and physical function in allo-HSCT recipients.
One study investigated the relationship between GVHD and physical function in 40 allo-HSCT patients and found that allo-HSCT patients had a 6% loss of muscle strength 1 month after the transplantation, whereas patients with acute GVHD had a 12% loss of muscle strength in the same timeframe. In summary, allo-HSCT patients frequently experience decreased muscle strength, exercise capacity, and QOL after transplantation, and there are differences between men and women. Compounding factors of impaired physical function included increased fatigue, lower muscle mass, decreased physical activity, decreased skeletal muscle oxygenation, donor type, and GVHD.
| Physical Exercise Improves Physical Function for Allogeneic Hematopoietic Stem Cell Transplantation Patients|| |
A systematic review and meta-analysis of 11 randomized controlled trials (RCTs), which included patients undergoing either allogeneic or autologous HSCT (n = 734), showed that physical exercise which includes aerobic exercise, resistance training, and relaxing stretching exercises may have positive effects on the physiological, psychological, and psychosocial health of allo-HSCT patients. Physical exercise during hospitalization has been shown to lead to higher QOL and lower fatigue in allo-HSCT patients at the time of discharge from the hospital. This study suggested significant positive effects on QOL, fatigue, psychological well-being and distress, and physical functioning. Another systematic review that included 8 studies of allo-HSCT patients (n = 472) showed that physical exercise had a statistically significant, moderately favorable effect on cardiorespiratory fitness, lower extremity muscle strength, and fatigue. Small but significant positive effects were found for upper extremity muscle strength, overall QOL, and physical, emotional, and cognitive functioning in patients with both allogeneic and autologous HSCT. One RCT that investigated the effects of aerobic exercise in 64 allo- and auto-HSCT patients showed that a physical exercise regimen that combined aerobic endurance training on a bicycle ergometer, and ADL training showed significant positive effects in the training group in terms of strength, endurance, lung function, and QOL compared to the control group. Similarly, a moderate exercise program was shown to increase endurance performance, muscular strength, fatigue levels, and emotional states without posing additional risks to 47 allo-HSCT patients. Another RCT of allo-HSCT patients (n = 100) showed that regular, light-intensity exercise, including walking or biking, can lead to significantly better physical performance during the recovery period and a better perceived physical and emotional state.
Combined multimodal physical exercise has also been shown to have a significant effect on VO2 max and muscle strength, as measured by chest press, leg extension, right elbow flexor, right knee extensor, and functional performance (stair test) in 42 patients who underwent allo-HSCT. Furthermore, the physical exercise group showed significantly better results for the severity of postprocedure diarrhea and fewer days of total parenteral nutrition. Similarly, a 4–6-week structured physical exercise program has been shown to significantly improve treatment-related symptoms in 42 allo-HSCT patients. Another study investigated the effectiveness of endurance and resistance training sessions on physical function in 105 allo-HSCT patients in a home-based setting before hospital admission, during inpatient treatment, and during a 6–8-week period after discharge; the physical exercise group showed significant improvement in fatigue scores, physical fitness, physical functioning, and overall QOL.
The effectiveness of an outpatient physical exercise program for allo-HSCT patients has also been evaluated. All patients were randomly assigned to a supervised PE program (n = 64) or a usual care control group (n = 67). A 12-week outpatient program that included both aerobic and strength exercises showed that physical performance improved in allo-HSCT patients after the intervention. However, body composition, physical activity levels in daily life, fatigue, and QOL did not show improvement. Another study, which was not a RCT, investigated the effectiveness of physical exercise without a control group and showed that 12 patients who followed a 12-week individualized mild aerobic exercise program had significant improvements in fatigue after allo-HSCT. A 6-week physical exercise program with active exercise, muscle stretching, and treadmill walking resulted in significantly higher muscle strength in 9 allo-HSCT patients compared to 9 allo-HSCT patients in a control group.
Pulmonary exercise can also be beneficial for allo-HSCT patients, improving their pulmonary function and exercise capacity. In one program, inspiratory muscle training to improve early transplantation-related outcomes consisted of 40% maximal inspiratory pressure. As a result, the distance covered during an incremental shuttle walking test, 6MWT scores, respiratory muscle strength, and depression showed significant improvement in the treatment group (n = 20) compared to controls (n = 18). Among 11 allo-HSCT patients with bronchiolitis obliterans syndrome, those who received pulmonary rehabilitation had significantly improved 6MWT and physical functioning scores after rehabilitation compared to before.
In summary, physical exercise appears to offer several beneficial effects for allo-HSCT patients, including positive impacts on physical and emotional recovery following transplant therapy and possible acceleration of patients' return to health and function after the procedure. Even light aerobic exercise has been shown to have a beneficial effect on physical and emotional recovery. Thus, allo-HSCT patients should perform physical exercise to maintain physical function before admission, during hospitalization, and after discharge. Physical exercise should include resistance training and aerobic exercise, relaxation stretching, and pulmonary exercise and should be tailored to the patient's condition. A physiotherapist, exercise trainer, and hospital staff should prevent bleeding during exercise in patients with a low platelet count [Figure 3]. Further high-quality research is needed to determine optimal physical exercise interventions for allo-HSCT patients.
|Figure 3: Physical exercise before admission, during hospitalization, and after discharge|
Click here to view
| Feasibility of Physical Exercise for Allogeneic Hematopoietic Stem Cell Transplantation Patients|| |
Despite the health-related challenges that patients face after receiving allo-HSCT, they tend to have a relatively high adherence rate to physical exercise. One study showed that the adherence rate to a physical exercise plan of five sessions weekly during the inpatient period was 64% in myeloablative conditioning, 54% in reduced-intensity conditioning, and 63% in nonmyeloablative conditioning in 113 allo-HSCT patients. Another study reported a 90% average adherence rate to a supervised multimodal exercise program performed five times per week for 4–6 weeks during the inpatient period after allo-HSCT in 42 allo-HSCT patients; similarly, 12 elderly allo-HSCT patients in a different study showed an 85% adherence rate. However, in a different cohort of 59 hCT patients, the overall adherence rate to a 4-week outpatient progressive physical exercise after allo-HSCT was 61%. Another study showed that the adherence rate to physical exercise for the total expected training days was 74% in 227 allo-HSCT patients.
| Using Borg Scale in Physical Exercise|| |
Borg scale is a frequently used quantitative measure of perceived exertion during physical exercise in rehabilitation and particularly exercise testing. A previous study used the Borg scale on the intensity of the ADL training which was meant to match the patient's subjective feeling of “slightly strenuous” to “strenuous” (Borg scale). Another research study also used the Borg scale on target scores 12–14 for endurance and 14–16 for resistance exercises in allo-HSCT patients. Another study investigated the relationship between the Borg scale and intensity of resistance training and an exercise tolerance test in 28 allo-HSCT patients. Borg ratings increased with increasing load intensity during knee extension resistance training, both before and after HSCT. Furthermore, Borg ratings was found to be associated with heart rate and load intensity during exercise tolerance test in patients both before and after HSCT. The Borg scale could be useful to determine the intensity of physical exercise in patients who have undergone allo-HSCT.
| The Relationship between Physical Function and Survival Rate and Mortality|| |
In a previous RCT of allo-HSCT patients, the physical exercise group (n = 50) had a significantly lower total mortality rate than the control group (n = 53), suggesting that physical exercise after allo-HCT improves survival after discharge in this patient group. Another report showed that patients presenting with a pre-HSCT 6MWT of <400 m who experienced a decline in 6MWT post-HSCT had the highest risk of nonrelapse mortality in 407 allo-HSCT patients. The same study found that pretransplant 6MWT is a significant univariate predictor of clinical outcomes in hematological patients beyond age but not beyond that of performance status. Similarly, a different study reported that patients with pre-HSCT peak VO2 <16 mL/kg/min had a higher risk of mortality post-HSCT and more hospitalized days before day 100 in both allogeneic (n = 11) and autologous (n = 11) HSCT patients. Furthermore, peak VO2 pre-HSCT is feasible and might predict symptom severity, QOL, and mortality.
| Conclusions|| |
Allo-HSCT patients require physical exercise to prevent a decrease in physical function or improve physical function. Future studies are required for allo-HSCT patients. For example, causes and strategies for prevention of decreases in physical function after HSCT have not been clarified. The use of corticosteroids and decreases in physical activity post-HSCT seem to be related to decreases in physical function. However, other factors may influence decreases in the physical function of allo-HSCT patients. These patients experience nausea, loss of appetite, and GVHD and tend to experience a decline in nutritional status and weight, which leads to muscle loss and loss of physical vitality. Therefore, future studies on the effects of nutritional therapy combined with physical exercise for allo-HSCT patients are needed. Moreover, as exercise capacity may be related to mortality in allo-HSCT patients, it is possible that muscle strength and physical activity could have a relationship with mortality in these patients. Future studies should investigate these possible relationships. Finally, future long-term follow-up studies focusing on the long-term physical function and overall QOL are needed. The survival rates of allo-HSCT patients have been improving, with many allo-HSCT patients living longer than those in the past. Thus, the maintenance of physical function, and its relationship to physical exercise should be investigated in long-term survivors of allo-HSCT in addition to inpatient populations.
The current review suggests that physical exercise is beneficial for the physiological, psychological, and psychosocial health of allo-HSCT patients. Thus, clinicians should encourage patients to perform physical exercise before, during, and after transplantation, and physical exercise should be integrated into the conditioning and recovery plans for all allo-HSCT patients.
The authors are thankful to the entire management of the Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan, for their support and encouragement.
Financial support and sponsorship
This study was supported in part by a Grant-in-Aid for Niigata University of Health and Welfare as well as the M. D. Anderson Cancer Center support grant CA 016672.
Conflicts of interest
There are no conflicts of interest.
| References|| |
Shapira MY, Tsirigotis P, Resnick IB, Or R, Abdul-Hai A, Slavin S, et al.
Allogeneic hematopoietic stem cell transplantation in the elderly. Crit Rev Oncol Hematol 2007;64:49-63.
Hatzimichael E, Tuthill M. Hematopoietic stem cell transplantation. Stem Cells Cloning 2010;3:105-17.
Niederwieser D, Baldomero H, Szer J, Gratwohl M, Aljurf M, Atsuta Y, et al.
Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey. Bone Marrow Transplant 2016;51:778-85.
Gyurkocza B, Rezvani A, Storb RF. Allogeneic hematopoietic cell transplantation: The state of the art. Expert Rev Hematol 2010;3:285-99.
Tabbara IA, Zimmerman K, Morgan C, Nahleh Z. Allogeneic hematopoietic stem cell transplantation: Complications and results. Arch Intern Med 2002;162:1558-66.
Smith AR, Wagner JE. Alternative haematopoietic stem cell sources for transplantation: Place of umbilical cord blood. Br J Haematol 2009;147:246-61.
Yang L, Tan Y, Shi J, Zhao Y, Zhu Y, Hu Y, et al.
Allogeneic hematopoietic stem cell transplantation should be in preference to conventional chemotherapy as post-remission treatment for adults with lymphoblastic lymphoma. Bone Marrow Transplant 2018;53:1340-4.
Villarreal CD, Alanis JC, Pérez JC, Candiani JO. Cutaneous graft-versus-host disease after hematopoietic stem cell transplant – A review. An Bras Dermatol 2016;91:336-43.
McDonald GB. How I treat acute graft-versus-host disease of the gastrointestinal tract and the liver. Blood 2016;127:1544-50.
Pidala J, Anasetti C, Jim H. Quality of life after allogeneic hematopoietic cell transplantation. Blood 2009;114:7-19.
Kurosawa S, Oshima K, Yamaguchi T, Yanagisawa A, Fukuda T, Kanamori H, et al.
Quality of life after allogeneic hematopoietic cell transplantation according to affected organ and severity of chronic graft-versus-host disease. Biol Blood Marrow Transplant 2017;23:1749-58.
Mohty B, Mohty M. Long-term complications and side effects after allogeneic hematopoietic stem cell transplantation: An update. Blood Cancer J 2011;1:e16.
Kapucu S, Karacan Y. Physiological problems in patients undergoing autologous and allogeneic hematopoietic stem cell transplantation. Asia Pac J Oncol Nurs 2014;1:50-4. [Full text]
Toubai T, Sun Y, Reddy P. GVHD pathophysiology: Is acute different from chronic? Best Pract Res Clin Haematol 2008;21:101-17.
Lee SJ. Classification systems for chronic graft-versus-host disease. Blood 2017;129:30-7.
Morishita S, Kaida K, Setogawa K, Kajihara K, Ishii S, Ikegame K, et al.
Safety and feasibility of physical therapy in cytopenic patients during allogeneic haematopoietic stem cell transplantation. Eur J Cancer Care (Engl) 2013;22:289-99.
Morishita S, Kaida K, Yamauchi S, Wakasugi T, Yoshihara S, Taniguchi K, et al
. Gender differences in health-related quality of life, physical function and psychological status among patients in the early phase following allogeneic haematopoietic stem cell transplantation. Psychooncology 2013;22:1159-66.
Morishita S, Kaida K, Yamauchi S, Wakasugi T, Ikegame K, Kodama N, et al.
Early-phase differences in health-related quality of life, psychological status, and physical function between human leucocyte antigen-haploidentical and other allogeneic haematopoietic stem cell transplantation recipients. Eur J Oncol Nurs 2015;19:443-50.
Wiskemann J, Huber G. Physical exercise as adjuvant therapy for patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplant 2008;41:321-9.
Morishita S, Kaida K, Ikegame K, Yoshihara S, Taniguchi K, Okada M, et al.
Impaired physiological function and health-related QOL in patients before hematopoietic stem-cell transplantation. Support Care Cancer 2012;20:821-9.
Morishita S, Kaida K, Tanaka T, Itani Y, Ikegame K, Okada M, et al.
Prevalence of sarcopenia and relevance of body composition, physiological function, fatigue, and health-related quality of life in patients before allogeneic hematopoietic stem cell transplantation. Support Care Cancer 2012;20:3161-8.
Ishikawa A, Otaka Y, Kamisako M, Suzuki T, Miyata C, Tsuji T, et al.
Factors affecting lower limb muscle strength and cardiopulmonary fitness after allogeneic hematopoietic stem cell transplantation. Support Care Cancer 2018. Doi: 10.1007/s00520-018-4433-5.
Wood WA, Deal AM, Reeve BB, Abernethy AP, Basch E, Mitchell SA, et al.
Cardiopulmonary fitness in patients undergoing hematopoietic SCT: A pilot study. Bone Marrow Transplant 2013;48:1342-9.
van Haren IEPM, Staal JB, Potting CM, Atsma F, Hoogeboom TJ, Blijlevens NMA, et al.
Physical exercise prior to hematopoietic stem cell transplantation: A feasibility study. Physiother Theory Pract 2018;34:747-56.
Jarden M, Hovgaard D, Boesen E, Quist M, Adamsen L. Pilot study of a multimodal intervention: Mixed-type exercise and psychoeducation in patients undergoing allogeneic stem cell transplantation. Bone Marrow Transplant 2007;40:793-800.
Morishita S, Kaida K, Yamauchi S, Sota K, Ishii S, Ikegame K, et al.
Relationship between corticosteroid dose and declines in physical function among allogeneic hematopoietic stem cell transplantation patients. Support Care Cancer 2013;21:2161-9.
Morishita S, Kaida K, Aoki O, Yamauchi S, Wakasugi T, Ikegame K, et al.
Balance function in patients who had undergone allogeneic hematopoietic stem cell transplantation. Gait Posture 2015;42:406-8.
de Souza CV, Miranda EC, Garcia C Jr., Aranha FJ, de Souza CA, Vigorito AC, et al.
Functional evaluation indicates physical losses after hematopoietic stem cell transplantation. Rev Bras Hematol Hemoter 2012;34:345-51.
Takekiyo T, Dozono K, Mitsuishi T, Murayama Y, Maeda A, Nakano N, et al.
Effect of exercise therapy on muscle mass and physical functioning in patients undergoing allogeneic hematopoietic stem cell transplantation. Support Care Cancer 2015;23:985-92.
Takekiyo T, Dozono K, Nara S, Murayama Y, Minamihama N, Nakano N, et al.
Gender differences in physical function and muscle mass change in patients undergoing allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 2017;52:1460-2.
Morishita S, Kaida K, Yamauchi S, Wakasugi T, Yoshihara S, Taniguchi K, et al.
Gender differences in health-related quality of life, physical function and psychological status among patients in the early phase following allogeneic haematopoietic stem cell transplantation. Psychooncology 2013;22:1159-66.
Danaher EH, Ferrans C, Verlen E, Ravandi F, van Besien K, Gelms J, et al.
Fatigue and physical activity in patients undergoing hematopoietic stem cell transplant. Oncol Nurs Forum 2006;33:614-24.
Morishita S, Kaida K, Yamauchi S, Wakasugi T, Ikegame K, Ogawa H, et al.
Relationship of physical activity with physical function and health-related quality of life in patients having undergone allogeneic haematopoietic stem-cell transplantation. Eur J Cancer Care (Engl) 2017;26. Doi: 10.1111/ecc.12669.
Morishita S, Wakasugi T, Kaida K, Itani Y, Ikegame K, Ogawa H, et al.
Fatigue, muscle oxygen consumption and blood flow to the skeletal muscle after allogeneic hematopoietic stem cell transplantation. Adv Exp Med Biol 2018;1072:293-8.
Wakasugi T, Morishita S, Kaida K, Itani Y, Kodama N, Ikegame K, et al.
Impaired skeletal muscle oxygenation following allogeneic hematopoietic stem cell transplantation is associated with exercise capacity. Support Care Cancer 2018;26:2149-60.
Wakasugi T, Morishita S, Kaida K, Itani Y, Kodama N, Ikegame K, et al.
Hemoglobin dynamics in the skeletal muscle of patients with malignant hematopoietic disease. Adv Exp Med Biol 2018;1072:287-91.
Takekiyo T, Dozono K, Mitsuishi T, Nara S, Yoshida K, Murayama Y, et al.
Recovery of physical function and quality of life in patients undergoing hematopoietic stem cell transplantation: A 1-year follow-up. Bone Marrow Transplant 2016;51:1127-30.
Kramer M, Heussner P, Herzberg PY, Andree H, Hilgendorf I, Leithaeuser M, et al.
Validation of the grip test and human activity profile for evaluation of physical performance during the intermediate phase after allogeneic hematopoietic stem cell transplantation. Support Care Cancer 2013;21:1121-9.
van Haren IE, Timmerman H, Potting CM, Blijlevens NM, Staal JB, Nijhuis-van der Sanden MW, et al.
Physical exercise for patients undergoing hematopoietic stem cell transplantation: Systematic review and meta-analyses of randomized controlled trials. Phys Ther 2013;93:514-28.
Persoon S, Kersten MJ, van der Weiden K, Buffart LM, Nollet F, Brug J, et al.
Effects of exercise in patients treated with stem cell transplantation for a hematologic malignancy: A systematic review and meta-analysis. Cancer Treat Rev 2013;39:682-90.
Baumann FT, Kraut L, Schüle K, Bloch W, Fauser AA. A controlled randomized study examining the effects of exercise therapy on patients undergoing haematopoietic stem cell transplantation. Bone Marrow Transplant 2010;45:355-62.
Baumann FT, Zopf EM, Nykamp E, Kraut L, Schüle K, Elter T, et al.
Physical activity for patients undergoing an allogeneic hematopoietic stem cell transplantation: Benefits of a moderate exercise intervention. Eur J Haematol 2011;87:148-56.
DeFor TE, Burns LJ, Gold EM, Weisdorf DJ. A randomized trial of the effect of a walking regimen on the functional status of 100 adult allogeneic donor hematopoietic cell transplant patients. Biol Blood Marrow Transplant 2007;13:948-55.
Jarden M, Baadsgaard MT, Hovgaard DJ, Boesen E, Adamsen L. A randomized trial on the effect of a multimodal intervention on physical capacity, functional performance and quality of life in adult patients undergoing allogeneic SCT. Bone Marrow Transplant 2009;43:725-37.
Jarden M, Nelausen K, Hovgaard D, Boesen E, Adamsen L. The effect of a multimodal intervention on treatment-related symptoms in patients undergoing hematopoietic stem cell transplantation: A randomized controlled trial. J Pain Symptom Manage 2009;38:174-90.
Wiskemann J, Dreger P, Schwerdtfeger R, Bondong A, Huber G, Kleindienst N, et al.
Effects of a partly self-administered exercise program before, during, and after allogeneic stem cell transplantation. Blood 2011;117:2604-13.
Knols RH, de Bruin ED, Uebelhart D, Aufdemkampe G, Schanz U, Stenner-Liewen F, et al.
Effects of an outpatient physical exercise program on hematopoietic stem-cell transplantation recipients: A randomized clinical trial. Bone Marrow Transplant 2011;46:1245-55.
Carlson LE, Smith D, Russell J, Fibich C, Whittaker T. Individualized exercise program for the treatment of severe fatigue in patients after allogeneic hematopoietic stem-cell transplant: A pilot study. Bone Marrow Transplant 2006;37:945-54.
Mello M, Tanaka C, Dulley FL. Effects of an exercise program on muscle performance in patients undergoing allogeneic bone marrow transplantation. Bone Marrow Transplant 2003;32:723-8.
Barǧı G, Güçlü MB, Arıbaş Z, Akı ŞZ, Sucak GT. Inspiratory muscle training in allogeneic hematopoietic stem cell transplantation recipients: A randomized controlled trial. Support Care Cancer 2016;24:647-59.
Tran J, Norder EE, Diaz PT, Phillips GS, Elder P, Devine SM, et al.
Pulmonary rehabilitation for bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2012;18:1250-4.
Wiskemann J, Herzog B, Kuehl R, Schmidt ME, Steindorf K, Schwerdtfeger R, et al.
Impact of HSCT conditioning and glucocorticoid dose on exercise adherence and response. Med Sci Sports Exerc 2017;49:2143-50.
Schuler MK, Hornemann B, Pawandenat C, Kramer M, Hentschel L, Beck H, et al.
Feasibility of an exercise programme in elderly patients undergoing allogeneic stem cell transplantation – A pilot study. Eur J Cancer Care (Engl) 2016;25:839-48.
Morris GS, Brueilly KE, Scheetz JS, de Lima MJ. Adherence of stem cell transplant recipients receiving glucocorticoid therapy to an exercise-based rehabilitation program. Support Care Cancer 2012;20:2391-8.
Casillas JM, Gudjoncik A, Gremeaux V, Aulagne J, Besson D, Laroche D, et al.
Assessment tools for personalizing training intensity during cardiac rehabilitation: Literature review and practical proposals. Ann Phys Rehabil Med 2017;60:43-9.
Morishita S, Wakasugi T, Tanaka T, Harada T, Kaida K, Ikegame K, et al.
Changes in borg scale for resistance training and test of exercise tolerance in patients undergoing allogeneic hematopoietic stem cell transplantation. Support Care Cancer 2018;26:3217-23.
Wiskemann J, Kleindienst N, Kuehl R, Dreger P, Schwerdtfeger R, Bohus M, et al.
Effects of physical exercise on survival after allogeneic stem cell transplantation. Int J Cancer 2015;137:2749-56.
Jones LW, Devlin SM, Maloy MA, Wood WA, Tuohy S, Espiritu N, et al.
Prognostic importance of pretransplant functional capacity after allogeneic hematopoietic cell transplantation. Oncologist 2015;20:1290-7.
[Figure 1], [Figure 2], [Figure 3]
|This article has been cited by|
||Symptom Burden and Recovery in the First Year After Allogeneic Hematopoietic Stem Cell Transplantation
| ||Linda Victoria Eriksson, Katarina Holmberg, Carina Lundh Hagelin, Yvonne Wengström, Karin Bergkvist, Jeanette Winterling |
| ||Cancer Nursing. 2023; 46(1): 77 |
|[Pubmed] | [DOI]|
||Balance Function after Balance Exercise Assist Robot Therapy in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Pilot Study
| ||Koichiro Sota, Yuki Uchiyama, Katsuji Kaida, Tatsushi Wakasugi, Daiki Takemura, Naoki Sasanuma, Kazuhiro Ikegame, Kazuhisa Domen |
| ||Progress in Rehabilitation Medicine. 2023; 8(0): n/a |
|[Pubmed] | [DOI]|
||Factors associated with changes in healthy lifestyle behaviors among hematological cancer patients during the COVID-19 pandemic
| ||Nienke Zomerdijk, Michelle I. Jongenelis, Ben Collins, Jane Turner, Camille E. Short, Andrew Smith, Kathryn Huntley |
| ||Frontiers in Psychology. 2023; 14 |
|[Pubmed] | [DOI]|
||A Scoping Review on Outcomes and Outcome Measurement Instruments in Rehabilitative Interventions for Patients with Haematological Malignancies Treated with Allogeneic Stem Cell Transplantation
| ||Anastasios I. Manettas, Panagiotis Tsaklis, Dario Kohlbrenner, Lidwine B. Mokkink |
| ||Current Oncology. 2022; 29(7): 4998 |
|[Pubmed] | [DOI]|
||The use of biocompatible composite scaffolds in oncology
| ||O. I. Kit, A. Yu. Maksimov, I. A. Novikova, A. S. Goncharova, E. A. Lukbanova, A. O. Sitkovskaya, V. G. Volovik, S. V. Chapek |
| ||Siberian journal of oncology. 2022; 21(1): 130 |
|[Pubmed] | [DOI]|
||Therapeutic Effects of Physical Exercise and the Mesenchymal Stem Cell Secretome by Modulating Neuroinflammatory Response in Multiple Sclerosis
| ||Lina María González, Laura Natalia Ospina, Laura Elena Sperling, Orlando Chaparro, Jaison Daniel Cucarián |
| ||Current Stem Cell Research & Therapy. 2022; 17(7): 621 |
|[Pubmed] | [DOI]|
||Physical activity counseling during and following stem cell transplantation – patients' versus advisors' perspectives
| ||C. Meyer-Schwickerath, M. Köppel, R. Kühl, G. Huber, J. Wiskemann |
| ||Journal of Communication in Healthcare. 2022; : 1 |
|[Pubmed] | [DOI]|
||Preparation is key: Prehabilitation for patients receiving high-dose chemotherapy and autologous stem cell transplant
| ||Suvir Singh, Gurkirat Kaur |
| ||Cancer Research, Statistics, and Treatment. 2022; 0(0): 0 |
|[Pubmed] | [DOI]|
||Exercise Interventions During Hospitalization for Stem Cell Transplantation: An Integrative Review
| ||Gisele C. Tlusty, Windy W. Alonso, Ann M. Berger |
| ||Western Journal of Nursing Research. 2022; : 0193945922 |
|[Pubmed] | [DOI]|
Evaluation of a
exercise and relaxation rehabilitation program during hospitalization for allogeneic hematopoietic stem cell transplant
| ||Encarna Camacho Pérez, Samantha Mayo, Jeffrey H. Lipton, Eugene Chang, Lyndsey De Souza, Daniel Santa Mina |
| ||PM&R. 2022; |
|[Pubmed] | [DOI]|
||Health care professionals’ understanding of contraindications for physical activity advice in the setting of stem cell transplantation
| ||Corinna Meyer-Schwickerath, Maximilian Köppel, Rea Kühl, Janina Bujan Rivera, Angeliki Tsiouris, Gerhard Huber, Joachim Wiskemann |
| ||Supportive Care in Cancer. 2022; |
|[Pubmed] | [DOI]|
||Analysis of factors associated with patient-reported physical functioning scores at discharge of allogeneic hematopoietic stem cell transplantation patients: a cross-sectional study
| ||Masanobu Murao,Ryota Hamada,Tadakazu Kondo,Junsuke Miyasaka,Michiko Yoshida,Honami Yonezawa,Yasuyuki Arai,Junya Kanda,Manabu Nankaku,Ryosuke Ikeguchi,Akifumi Takaori-Kondo,Shuichi Matsuda |
| ||Supportive Care in Cancer. 2021; |
|[Pubmed] | [DOI]|
||An Exploratory Study on Physical Function in Stem Cell Transplant Patients Undergoing Corticosteroid Treatment for Acute Graft-Versus-Host-Disease
| ||An Ngo-Huang,Rajesh Yadav,Swati Bansal,Janet Williams,Jimin Wu,Jack B. Fu,Amin M. Alousi,Eduardo Bruera |
| ||American Journal of Physical Medicine & Rehabilitation. 2021; 100(4): 402 |
|[Pubmed] | [DOI]|
||Weight Loss Intervention before Cord Blood Transplantation in an Obese Patient with Acute Myeloid Leukemia: A Case Study
| ||Ryuichi Kasahara,Takaaki Fujita,Ryohei Jinbo,Tatsuyuki Kai,Yuichi Yamamoto,Shinichiro Morishita,Miki Furukawa,Yutaka Shiga,Hideo Kimura,Masahiko Fukatsu,Kayo Harada,Satoshi Kimura,Takayuki Ikezoe |
| ||Progress in Rehabilitation Medicine. 2021; 6(0): n/a |
|[Pubmed] | [DOI]|
||Implementing a Feasible Exercise Programme in an Allogeneic Haematopoietic Stem Cell Transplantation Setting—Impact on Physical Activity and Fatigue
| ||Annika Kisch,Sofie Jakobsson,Anna Forsberg |
| ||International Journal of Environmental Research and Public Health. 2020; 17(12): 4302 |
|[Pubmed] | [DOI]|
||Exercise before, during, and after Hospitalization for Allogeneic Hematological Stem Cell Transplant: A Feasibility Randomized Controlled Trial
| ||Daniel Santa Mina,Lianne B. Dolan,Jeffrey H. Lipton,Darren Au,Encarna Camacho Pérez,Alyssa Franzese,Shabbir M. H. Alibhai,Jennifer M. Jones,Eugene Chang |
| ||Journal of Clinical Medicine. 2020; 9(6): 1854 |
|[Pubmed] | [DOI]|
||The efficacy of specialised rehabilitation using the Op-reha Guide for cancer patients in palliative care units: protocol of a multicentre, randomised controlled trial (JORTC-RHB02)
| ||Nanako Nishiyama,Yoshinobu Matsuda,Noriko Fujiwara,Keisuke Ariyoshi,Shunsuke Oyamada,Keiichi Narita,Ryouhei Ishii,Satoru Iwase |
| ||BMC Palliative Care. 2020; 19(1) |
|[Pubmed] | [DOI]|
||Evaluation of quality of life and its influencing factors after transplantation of leukemia patients based on SF-36 score: a cohort study
| ||Wenjun Xie,Xiaoyu Zhang,Jiao Wang,Jinghui Zhang,Jie Liu,Bei Wang,Wei Guan,Huijuan Zhang,Li Xu,Guiying Liu,Sizhou Feng,Changping Li,Mingzhe Han |
| ||Quality of Life Research. 2020; |
|[Pubmed] | [DOI]|